Anupama Samantasinghar

3 Questions 4 Answers 0 Followers

Questions related from Anupama Samantasinghar

Hello everyone , hope you all are doing well. can anyone please suggest me a protocol to make a thiol containing myatansinoid to a thiol free ?

I want to make a thiol containing myatansinoid or DM1 compound into thiol free for conjugation process without diminishing it's cytotoxic potential.

15 November 2021 341 2 View

How to prepare 50 mM potassium phosphate (KPi)/50 mM sodium chloride (NaCl)/2 mM ethylenediaminetetraacetic acid (EDTA), pH 6.5 buffer solution?

Can anyone guide me how could I prepare this buffer? Should I first prepare 50mM potassium phosphate then 2 mM ethylenediaminetetraacetic acid (EDTA) .Then I should mix them and pH should...

14 October 2021 1,648 1 View

Hello, I want to ask that during Antibody drug conjugate (ADC) development, how to store antibody-linker conjugation?

I have prepared an Antibody-linker conjugation, and I filtered out the unbound linkers from the solution but before further conjugation of payload to it, I want to store it, Can anyone please...

13 October 2021 1,806 5 View