Should % peak area be calculated separately for ESI+ and ESI− modes, or is it acceptable to combine the response values from both modes ?

I’m currently working on LC-QTOF-MS/MS profiling of phenolic compounds, and like you, I detect some metabolites only in ESI−, some only in ESI+, and a few in both modes. I understand that...

12 June 2025 4,168 1 View