Why do I observe an increase in the mutant allele (A) after using ABE8e base editors, which are expected to convert A to G?

I used two adenine base editors—ABE8e-SpRY and ABE8e-NG—to target a heterozygous mutation site where the wild-type allele is G and the mutant allele is A. The goal was to convert the A (mutant)...

01 May 2025 9,967 0 View