Alastair B Ross

3 Questions 12 Answers 0 Followers

Questions related from Alastair B Ross

Protocols for purification of of LC-MS grade solvents?

We have recently been finding that some of our LC-MS grade solvents have impurities (several brands) - notably acetonitrile and methanol. To avoid future problems, we would like to do an in-lab...

09 August 2023 936 4 View

Mass spec sample cone is getting very dirty very quickly when running plasma samples - any ideas why?

We are developing a method to analyse some low molecular weight compounds in plasma using LC-MS/MS. The sample preparation is a simple protein crash with methanol with 0.1 % formic acid, together...

10 February 2016 9,708 5 View

Has anyone come across m/z 389 and 417 as contaminants in APCI positive LC-MS?

We are running LC-MS/MS with APCI in positive mode, and at the moment have a really high background, even when running in MRM mode. We have a couple of masses which are really high, m/z 389 and...

05 March 2015 9,420 4 View