Why Tetrafluoroboric acid diethyl ether complex (HBF4.Et2O) would be used over HCl for protonation in a 9:1 MeOH:H2O mixture?

Hi, I recently came across a paper where the authors protonated their molecule in ACN using HBF4.Et2O. My question is, if I had a solvent mixture of 90:10 MeOH:H2O, would the HBF4.Et2O acid work...

01 April 2020 7,867 3 View