Despite the fact of the tremendous number of research papers in the literature dealing with the usage of aptamers as molecular probes in biosensing, and despite the fact that this technology is almost 30 years old, there is only just few companies producing aptasensors and aptaessays and the majority of them are startups, and almost no commercial biosensor or kits is currently available in the market.
Can anyone explain to me why there is such gap?
It may be due to the stability issues. Aptamers are prone to quick degradation under certain environmental conditions.
It may be due to the stability issues. Aptamers are prone to quick degradation under certain environmental conditions.
Definitely stability issues. DNASe and RNAse are very efficient and ubiquitous especially in biological matrices. People have tried to modify the aptamers to overcome this issue with negative outcomes of sensitivity and specificity.
Also people are developing AptaMIPs but shield the apatamer but steric hindrance to ligand binding is a major issue.
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