O.M. Ahmed, R.G. Ahmed, A.W. El-Gareib, A.M. El-Bakry, S.M. Abd El-Tawaba, 2012. Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: II-The developmental pattern of neurons in relation to oxidative stress and antioxidant defense system. Int. J. Dev. Neurosci. 30, 517–537. http://dx.doi.org/10.1016/j.ijdevneu.2012.04.005.

in a hyperthyroid state, several studies

(Komosinska-Vessev et al., 2000; Abalovich et al., 2003; Bednarek

et al., 2004a,b) have indicated an imbalance between oxidant/

antioxidant status and enhanced oxidative stress in plasma

and/or other tissues. Even more interesting is the elegant studies

discussed by Goswami et al. (2003), Cetinkaya et al. (2005) and

Guerra et al. (2005) who proposed that oxidative stress correlates

with signs and symptoms of hyperthyroidism. Previously,

Fernández et al. (1985) and Asayama et al. (1987) speculated that

the hypermetabolic state in hyperthyroidism is associated with

increases in free radicals production and lipid peroxide levels in

rats. In addition, increased oxidative stress (Komosinska-Vessev

et al., 2000; Abalovich et al., 2003; Reid and Wheeler, 2005) and

impairment of cellular and extracellular antioxidant systems

(imbalance of antioxidant/oxidant status) may play a role in the

pathogenesis of Graves’ disease (Komosinska-Vessev et al., 2000;

Abalovich et al., 2003). Administration of L-T4 (100 g/kg) to

rabbits for 21 days caused an increase in LPO and a decrease

in the concentration of vitamins C and E (Kowalczyk et al., 2003;

Al-Rubae’i and Al-Musawi, 2011). Mogulkoc et al. (2005) recorded

that high-dose of T4 administration in hypothyroid rats increased

oxidative damage in cerebrum and that this damage could not be

prevented despite the increase in the antioxidant system activity.

Moreover, in human, oxidative stress plays an important role in

hyperthyroidism-induced tissue damage (Bednarek et al., 2004a).

Also, hyperthyroidism in man is characterized by significant

changes in circulating parameters related to oxidative stress as (1)

increased levels of lipid peroxides (Yavuz et al., 2004; Al-Rubae’i

and Al-Musawi, 2011), (2) elevated levels of H2O2 and lipid

hydroperoxides (Bednarek et al., 2004b) and (3) reduced levels of

thiols (Adali et al., 1999; Komosinska-Vessev et al., 2000), ascorbic

acid (Ademo˘glu et al., 1998; Seven et al., 1998), -tocopherol

(Ademo˘glu et al., 1998; Bianchi et al., 1999) and GPx (Ademo˘glu

et al., 1998).

Oxidative stress probably play an important role in pathogenesis of manifestation of hyperthyroidism. So theoretically antioxidants should have an important role in its management. However study results are not very encouraging but they have probably some benefit.. You can follow the following links.. Thanks

https://www.ncbi.nlm.nih.gov/pubmed/8960788

https://www.ncbi.nlm.nih.gov/pubmed/15061353

https://www.intechopen.com/books/antioxidant-enzyme/oxidative-stress-and-antioxidant-status-in-hypo-and-hyperthyroidism

yes antioxidants play important role to control hypothyroidism

Indeed both hyperthyroidism and hypothyroidism are associated with enhanced oxidative stress involving enzymatic and non-enzymatic antioxidants. Furthermore, some complications of hyperthyroidism are specifically related to the oxidative stress in target tissues.

Article Thyroid Hormones and Antioxidant Systems: Focus on Oxidative...

Thyroid hormones have an important role in antioxidant system modulation.