it depends on which admixture are you using. For example if you employ air entrainment admixtures will improve the durability of the concrete in the cases that this concrete will exposed to cycles of freezing and thawing
The difference in the efficiency of admixtures due to their diversity and heterogeneity of chemical composition requires the user to be aware of the advantages and determinants of such materials so that a mixture can be produced without affecting the strength and durability.Generally, they are depending on many parameters.So it is possible to select admixture without affect on concrete after a late age.
Most of the admixtures are used to enhance some of the property of concrete in other words they improve the performance of concrete in terms of workability and strength in long run. Most of the admixtures are manufactured keeping in mind that they do not have adverse effect on durability rather they should improve the durability of concrete.
It depends on the type of the admixture and the purpose that you are using for. Generally, admixtures are used to improve the properties of concrete including the durability..