I am doing RSM and the results gave a low R-square model (both full quadratic and reduced model) but the lack-of-fit P-value is high (>0.05) how is it that R-square says the model does not fit but the lack-of-fit statistics says it does? For additional info, I am using nature-based polymers (alginate and hydroxypropyl cellulose), is it because I'm using these?

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