Check most quality organic texts; scifinder scholar ir ISI Web of Science are good resources that use graphic interfaces. A good science librarian can assist you if these search tools are unavailable.

Hi Mihamed,

The following link should be helpful:

http://www.commonorganicchemistry.com/Rxn_Pages/Acid_to_Acid_Chloride/Acid_to_Acid_Chloride_Index.htm

Dear Mohamed Assaleh

First, to save your time and effort you can purchase the acid chloride which is available in sigma. (nicotinic acid chloride). But if you are planning to save money and prepare the acid chloride your self there are several methods previously reported. I have tried the first pathway myself and it was successful.

[A] https://pdfs.semanticscholar.org/6fff/4fcbcb06382927bd4c1cd07498b241706076.pdf

[B] http://www.prepchem.com/synthesis-nicotinoyl-chloride/

[C] http://rasayanjournal.co.in/vol-2/issue-2/26.pdf

Note,

it is necessary to use fume hood because of the liberated gases (SO2, HCl)

IF you are planning to react these acid chlorides with a strong nucleophile or amine you can try the preparation or the ester which react smoothly and slowly

Good Luck

Thank you all for your reply,

yes of course I am using fume hood and I tried before with Thionyl chloride /THF but was not good, Thionyl Chloride/ DMF which i was not satisfied of the result because after re-crystallization it didn't give me good FTIR spectra.