sometimes you send an important email to someone and you are just wondering whether they have seen the email or not.
this idea is employed in mobile messaging. some telecom companies send u msg notifying u of reception of your send message. or as seen used by facebook, whatsapp or other chat services.
But I feel this will be annoying. Imagine that for those in a companies that you have to do communications and sending e-mails like at least 10 e-mails a day with different people, management staff, other divisions staff, vendors, colleagues, issuing the ticket for the failed devices and so on... And in addition of the reply you get from your recipient regarding your issue, you get a confirmation e-mail as well. This really gonna be a headache for the companies.
It is called "certified email". Implemented in Italy since 2011, see https://en.wikipedia.org/wiki/Certified_email, it is legally equivalent to traditional registered mail. An RFC draft has been submitted (https://tools.ietf.org/html/rfc6109).
You are mixing two things here: non-repudiation means that the eMail from Sender 1 is digitally signed and no one but Sender 1 would have been able to produce this message.
The other thing is acknowledging that an eMail has been received. This is governed by https://tools.ietf.org/html/rfc6533 (the latest iteration of a few other RFCs), see also https://en.wikipedia.org/w/index.php?title=Return_receipt&oldid=691337429 for a quick overview and https://en.wikipedia.org/wiki/AS1_%28networking%29 for a combination with non-repudiation.
So, regarding you question on feasibility: the answer is yes.
from what i know Nonrepudiation is the assurance that someone cannot deny something. it goes beyond digital signatures. i did more reading and Email nonrepudiation involves methods such as email tracking that are designed to ensure that the sender cannot deny having sent a message and/or that the recipient cannot deny having received it.