Melatonin is known as the hormone of happiness, it was proven to have antioxidant activity in addition to antiinflammatory potentiality. Therefore, it may be of value in treatment of periodontal defects when used. Is it possible or not?also, what is more safe, topical or systemic application?
What are the most recent gingival crevicular biomarkers for oxidative stress?
Melatonin can be considered as one of the most important treatment lines for periodontal defects owing to its strong antiinflammatory & antioxidant properties. Many in vitro & in invivo studies have been emerged supporting its application.
Although melatonin could be advisable to support the treatment of periodontitis patients, the systemic effects might limit its use. Hence the topical application is quite advisable.
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