I am not in the Medical field myself, but I really admire it. However, as a person who uses stats in my job, it boggles my mind how we keep hearing that the folks doing medical studies have discovered "the gene responsible for X" or the "cause of Y". I really wonder how causation inference work in medical studies. Here is how I think about it:

It is safe to say that we can observe sets of conditions that frequently occur along with a phenomenon (correlation), and let's now focus on preconditions only (greatly simplifying the problem). I think that for a set of conditions to cause the phenomenon, they must each be necessary for the phenomenon and, together, they must be sufficient. Now, let's see if we can infer necessity and sufficiency. Necessity means that there is not a single observation of the phenomenon where the condition was missing. So, arguably we can infer necessity, albeit being a tough job and the result must be labelled by the infamous "to the best of our knowledge". Sufficiency is the one I am struggling with. Is it even theoretically possible that we infer that a set of conditions are sufficient, using empirical methods?

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