I would like to use 2-bromo pyridine to get 2-cyanopyridine I do need someone send me the procedure for synthesis.
Applied Organometallic Chemistry 28(10), 750-755; 2014
1mmol 2-bromopyridine, 1.1 mmol NaCN, 1.1 mmol K2CO3, 0.02 mol nickel ferrite nanoparticles was heated in 3 ml DMF for 40h under air atmosphere.
Chinese Journal of Chemistry 32(12), 1221-1224; (2014)
2-bromopyridine, benzoylcyanide and TMEDA are heated for 16h in DMF at 130°C with Cu(OAc)2 and Na2CO3 as catalyst.
Synthesis (20) 3351-3355; 2008
2-Brompyridine, K4Fe(CN)6, 1-methylimidazole, CuI as catalyst
Similar US 20090062541 (I think best precedure)
Siimilar Chemistry - A European Journal 13(12) 6249-6254; 2007
Similar Synlett (4) 555-558; 2007
Journal of Chemical Research, Synopses (12), 814-815; 2003
2-bromopyridine, CuCN in DMSO 2 min MW irradiation
https://www.google.ch/patents/US20090062541
Thank you for your answer
You can use Zinc cyanide instead of NACN with palladium catalyst using DMF as solvent
Thank you for your answer, would you please send me the procedure for that.
one could use Waxman and Thomas (1974) work?
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Thanks
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