Although I don't know a lot about matlab, I would highly recommend you to seek out network simulators instead. Network simulators are usually designed to scale and make it easier to produce reliable results. However, it also depends on which aspect of wireless communication you want to simulate. Do you want to focus on the physical transfer? Then matlab could do the job[1], if you use the right models for signal propagation and so on. However, many wireless communication simulation are especially interesting with respect to application performance. Some of the necessary protocols may not be available[2], or not offer sufficient implementation detail.
Since the layer aspect is missing in your question, it will be difficult for others to answer your question. Regardless of what choice you make for simulations, make sure that you try to document exactly which models and implementations you use, so that others can reproduce your results.
[1] for example, this company claims to have an 802.11p physical model implementation: http://www.ittiam.com/en/Silicon/IP-Portfolio/Wireless-LAN/Wireless-LAN-PHY-Model/80211p-PHY-Matlab-model.aspx
[2] for example, a quick search seems to reveal there is no satisfactory implementation of AODV (an ad-hoc routing protocol).
Thank you for your answer. In fact I'm working on a protocol to implement at the MAC layer, but which requires information provided by the physical layer like interference (collision) ocurence.