Mr. Ilaiyaraja,

You could pay attention to:

Biological activity: estrogenic effect and,

Other: orgenic electronics:

1. MITSUBISHI GAS CHEMICAL COMPANY, INC. Patent: EP610912 A2, 1994;

2. Mitsui Toatsu Chemicals, Inc. Patent: US5359117 A1, 1994;

3. Sumitomo Chemical Company, Limited, Patent: EP1248313 A2, 2002;

4. Patent: US2015/141692 A1, 2015;

5. Nippon Soda Co., Ltd.;Patent: US2015/353738 A1, 2015;

6. Patent: JP2015/205822 A, 2015;

7. NIPPON SODA CO., LTD.; Patent: TWI522346 B, 2016;

8. Patent: TW2016/5785 A, 2016;

9. Lee, C.; Lee, J., Org. Electr.: 2013, 14, 370-377

10. Song, S. et al. Polymer (United Kingdom), 2015, 64, 76-83

11. Kobayashi, S. et al. Bull. 2006, 54, 1633-1638

12. Chen, D. et al. Environm. Sci. Technol. 2016, 50, 5438-5453

13. Kurochkina; G. et al. Doklady Chemistry, 2000, 371, 43-47

14. Nifantev; R. et al. Russ. J. Gen. Chem. 2001, 71, 1325-1326

15. Ziegler; S. Monatshefte fuer Chemie, 1953, 84, 278,286

16. Union Carbide Corp. Patent: US2858342 , 1955;

17. Zincke; W. Justus Liebigs Annalen der Chemie, 1908, 363, 288.

18. Mackenzie, Journal of the Chemical Society, 1901, 79, 12091

Synthesis (attachment, synthetic scheme and synthetic steps):

Step [1]:

(a) Werts, M. et al. Macromolecules, 2003, 36, 7004-7013

Step [2]:

(a) Hydrogenchloride; Burton; C. J. Chem. Soc. 1955, 3089,3090

(b) Werts, Michel P. et al. Macromolecules, 2003, 36, 7004-7013

Step [3a]:

(a) Hydrogenchloride; diethyl ether; calcium chloride; J. Am. Chem. Soc. 1932, 54, 3250,3256

(b) Acetyl chloride in benzene; Adv. Synth. Catal. 2014, 356, 3755-3760

(c) Acetyl chloride in benzene; J. Org. Chem. 1991, 56, 7320-7322

Step [3b]:

(a) Diethyl ether; J. Am. Chem. Soc. 1923, 45, 219

(b) Benzene; J. Am. Chem. Soc. 1944, 66,415

Step [4a]:

(a) Stage #1: 1-bromo-4-methoxy-benzene With tetrahydrofuran; n-butyllithium in cyclohexane; Inert atmosphere; Stage #2: benzophenone, water in cyclohexane; Synthesis (Germany), 2012, 44, 2531-2536

(b) Stage #1: 1-bromo-4-methoxy-benzene With magnesium in tetrahydrofuran, Reflux; Stage #2: benzophenone in tetrahydrofuran, Reflux; Chem. - Eur. J. 2010, 16, 7469-7477

(c) Magnesium in tetrahydrofuran, Schlenk technique, Inert atmosphere; Adv. Synth. Catal. 2014, 356, 3755-3760.

Periyaiah Ilaiyaraja

For synthesis, see

--- Behr, Erich, Brit. (1970), GB 1184289 19700311

*PhOH and benzophenone chloride are reacted to give the title compd. (I) , useful as an intermediate. Thus, 188 g PhOH and 237 g pure (Ph) 2CCl2 are mixed under N, and the mixt. heated to 150°, then under vacuum. Workup gives 96 % I, m. 303- 5°.

For biological activity, see

--- Highly potent binding and inverse agonist activity of bisphenol A derivatives for retinoid- related orphan nuclear receptor RORγ, Nishigori, Mitsuhiro; Nose, Takeru; Shimohigashi, Yasuyuki Toxicology Letters (2012), 212(2), 205-211

--- Binary classification models for endocrine disrupter effects mediated through the estrogen receptor,  Roncaglioni, A.; Piclin, N.; Pintore, M.; Benfenati, E.,  SAR and QSAR in Environmental Research (2008), 19(7-8), 697-733.

--- Stereo structure- controlled and electronic structure- controlled estrogen- like chemicals to design and develop non- estrogenic bisphenol A analogs based on chemical hardness concept,  Kobayashi, Shigeki; Shinohara, Hidemi; Tabata, Kyoko; Yamamoto, Naoko; Miyai, Akira,  Chemical & Pharmaceutical Bulletin (2006), 54(12), 1633-1638.

For uses, see

---Polycarbonate copolymer composition with flame- retardance and chemical- resistance, Hwang, Young Young; Park, Jung Jun; Hong, Moo Ho,  PCT Int. Appl. (2016), WO 2016089134 A2 20160609.

Good luck