This question is truly pertinent and the answer to this lies at the heart of evolving role of precision in medicine.

Thanks for the response mam. # Evidence-based Precision Medicine.

As an extension of your comment, the extent to which practice is evidence-based and yet, personalised is a matter of debate.

I believe that guidelines are meant to be used for guidance only, and not as laws. Most guidelines nowadays give various options and conclude by advising an individualized management protocol, I personally appreciate all such guidelines.

Thanks Pranav for the befitting response.

I appreciate your viewpoint of personalising practice while following guidelines at the same time.

Thank you so much Dr Rohan

Many thanks for the positive interaction

Whilst guidelines provide a general 'guide' to a clinical situation, personal judgment is imperative.

Many thanks for replying on the thread.

@ Dr Ankur Jain.

Certainly, there is a definite impact @ Dr. Rohan Magoon.

Nevertheless, practice variability have its own unique role in clinical medicine whilst following the guidelines.

Thank you @ Dr Brajesh Kaushal.

For replying on the thread.

I think protocol based knowledge and clinical knowledge both are different things. After few years of clinical experience, everyone starts working on their own.

Thanks Dr Ohri.

I think both guideline-protocol-algorithm and personalized clinical judgment come one after another. When you are new to the fraternity, guidelines make you learn and prevent from doing any clinical misadventure. After years of practice, our clinical knowledge helps us to conduct researches and guidelines are being updated. So both of them are essential for betterment of the patient.

Certainly Dr Souvik.

Agreed

Very pertinent point Dr Jes Jose

But what about tuberculosis.

A reason mentioned for emergence of MDR TB in India is not adhering to national treatment protocols.

Thus, I believe guidelines are necessary , but yes they should allow all the available and effective options to enable us the benefits of latest developments and provide individualized personalized care.

Well put

Pranav Ish