How do you improve DCC coupling yield?

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Valentas Spiliauskas

extra info: monitoring reaction progress with HPLC-MS, and the complex with acid and amino acid (blocked) can both be seen as well as product, and diluting it doesn't work.

and apologies for a long description, I am a rookie in the field

Guobing Xiang

Valentas, could you show us the rx detail here?

1 eq. of 3 - nitro benzoic acid, 1 eq. of 4 methoxy aniline, 1.2 eq DCC, and 1 eq of TEA, in THF room temperature. doing reaction without HOBt. Reaction is performed with 10 grams of starting material.