G6PD deficiency is quite common in our anesthesia practice in the middle east. Intraop/postop analgesia in them is an issue here. Many websites/books give contrasting advise with former advocating avoidance/caution and the later silent on use of NSAIDS in patients with G6PD deficiency. Senior consultants we could talk to said that they are using inj diclofenac without bad effects, whereas some are avoiding totally thereby the patients are losing the important component of periop analgesia.
Is there any research paper/expert guideline on this issue?
Yes – paracetamol and NSAIDS (Nonsteroidal anti-inflammatory drugs) are safe for children with G6PD deficiency.
Yes NSAIDS and Glucose 6PD Deficiency not harmful, but in case of Aspirin caution should be taken because it can cause hemolysis accompanied by presence of oxidative stress due to other drugs or other non drug factors, At therapeutic doses Aspirin does not causes hemolysis in the absence of oxidative factors.
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