seem that a lack of common standards about studies of Nanoparticles cytotoxicity and others nanomateriais for interaction with living cells has been one of the limitations of the current research, mainly in neurosciences, which invoves diifferent cell lines, exposure times, and colorimetric assays that usec in different studies. For this reason, For this reason, I think that it is necessary we beginning a discussion about this theme so that will be possible to compare cytotoxic effect among these results, such as single standard meets all conditions for obtaining information on nanomaterials cytotoxicity. What do you say about this theme?
I absolutely agree, and tried to address this in some way in this work....
“Numerical simulations of in vitro nanoparticle toxicity – the case of Poly(amido amine) dendrimers”
Marcus A. Maher, Pratap C. Naha, Sourav Prassana Mukerjee, Hugh J. Byrne
Toxicology In Vitro, 28, 1449-1460 (2014)
I am agree with Prof. Hugh. We should look after the toxicity factor because now a days everyone is crazy with NMs but not with their toxicity. Hope, something solid result will come in near future.
Dear Colleagues,
For this reason that I propuse a large discussion about the formulation a toxicity standard of bionanomaterials.
There is a number of groups worldwide looking at this -in Europe, for example, the different Working Groups of the NanoSafety Cluster http://www.nanosafetycluster.eu/working-groups.html
I have been somewhat involved in some of the discussions and out comes
“How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology”,
Clemens Wittwehr, Hristo Aladjov, Gerald Ankley, Hugh J. Byrne, Joop de Knecht, Elmar Heinzle, Günter Klambauer, Brigitte Landesmann, Mirjam Luijten, Cameron MacKay, Gavin Maxwell, M.E. (Bette) Meek, Alicia Paini, Edward Perkins, Tomasz Sobanski, Dan Villeneuve, Katrina M. Waters, and Maurice Whelan,
Toxicological Sciences, accepted September (2016)
“The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design”,
Iseult Lynch, Arti Ahluwalia, Diana Boraschi, Hugh J. Byrne, Bengt Fadeel, Peter Gehr, Arno C. Gutleb, Michaela Kendall, Manthos G. Papadopoulos,
BioNanoMaterials. 14, 195–216 (2013)
“Concern-driven integrated toxicity testing strategies for nanomaterials - Report of the NanoSafety Cluster Working Group 10”,
Agnes Oomen, Peter Bos, Teresa Fernandes, Kerstin Hund-Rinke, Diana Boraschi, Hugh J. Byrne, Karin Aschberger, Stefania Gottardo, Frank von der Kammer, Dana Kühnel, Danail Hristozov, Antonio Marcomini, Lucia Migliore, Janeck Scott-Fordsmand, Peter Wick and Robert Landsiedel,
NanoToxicology, 8, 334-338 (2014)
“Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices”,
Hans Bouwmeester, Iseult Lynch, Hans J. P. Marvin, Kenneth A. Dawson, Markus Berges, Diane Braguer, Hugh J. Byrne, Alan Casey, Gordon Chambers, Martin J. D. Clift, Giuliano Elia, Teresa F. Fernandes, Lise B. Fjellsbo, Peter Hatto, Lucienne Juillerat, Christoph Klein, Wolfgang G. Kreyling, Carmen Nickel, Michael Riediker, Vicki Stone,
Nanotoxicology, 5, 1-11 (2011)
Thanks again. I am keep up with follow your sugestions of lecture
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