It is known that if z0 is a zero of entire function F(z) with multiplicity p, then z0 is a zero of their derivative but with multiplicity p-1. It is known also that is not true in general if we replace the derivative of F by the difference operator Delta(F)=F(z+1)-F(z). But, if we suppose that F and Delta(F) having the same zeros (not necessary with the same multiplicity). Can we say something about the comparison of the multiplicity of their zeros. In other words, Can we say that the order of the multiplicity of zeros of Delta(F) is less than the order of multiplicity of zeros of F.