For example my LOD value is 60.10-7 and my analyte concantration range is between 0.5.10-7 and 165.10-7
I think it can be.
1. Take a very simple example: Suppose that my LOD = 0.5. And my data are: 1, 3, 5, 107. So I use an extreme example where we do not have censored values, meaning that all observed values are above the LOD, but then the lower limit could fall below the LOD.
I obtained the mean of 29 and standard deviation (sd) = 52.02563.
Suppose that the data follow normal distribution (just a very rough example, so it is possible that this assumption is not true for the data at hand), you have 95% confidence interval of: (29-1.96*52.02583 ; 29_ 1.96*52.02583) = (-72.97024 ; 130.9702).
So the lower limit is -72.97 which is far less than the LOD which is 0.5 according my assumption.
So yes, it can be.
It can, but in order to find those limits you'll probably need to transform your data first (you cannot have a negative concentration, can you?)
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