Lesser periwinkle is a European species of Mediterranean origin, but the exact natural range of its distribution is unknown. In some geographical regions (e.g. in North America) lesser periwinkle is principally regarded as an invasive species, threatening native biodiversity. However, in Europe it was traditionally an indispensable part of indigenous knowledge. I aim to study especially its history in Central Europe, where its earliest appearance can be traced to the Roman Period. Various historical sources suggest that the plant has been known to have special magical and healing properties. Today, the plant is also used in archaeology as a botanical indicator of deserted Roman and medieval settlements, as it has often survived as a relic plant at their locations in the secondary forest over centuries.